General description

Immunohistochemical methods have localized chromogranin in a wide variety of endocrine tissues including the pituitary, pancreas, hypothalamus, thymus, thyroid, intestine, and parathyroid. Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin. It is generally accepted that the co-expression of certain keratins and chromogranin mean neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Legal Information

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Linkage

Chromogranin A Positive Control Slides, Product No. 238S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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Quality